INCI:Saccharomyces/Capsicum Annuum Fruit Ferment Filtrate, Leuconostoc/Radish Root Ferment Filtrate Use Levels: 0.5% - 15.0%
Capsaicin has been shown to induce apoptosis in many types of cancer cells. It is now thought that this is due to the localized increase in reactive oxygen species. This is only part of the story with regard to activity of Capsicum because it is clear that there are other components present in the fruit of the plant that can mobilize immune function. Perhaps more importantly Capsaicin inhibits angiogenesis. It is somewhat interesting that a product known to produce redness inhibits angiogenesis. The erythema found with topical application is no doubt a result of the increased ROS levels and not directly a result of increased circulation. But as with most plants, the activity of a single purified phytochemical does not always explain the activity of a less refined extract. Capsicum has widely been show to contain a high level of antioxidants ranging from ascorbic acid and glutathione to more robust enzymes such as Superoxide Dismutase. It has also been shown that by fermenting Capsicum a product is formed that will increase glutathione levels while at the same time stimulating immune function. This provided an interesting starting point for a new product. What if we were able to provide some of the benefits of a Capsicum extract without any of the associated irritation?