FSS CytoSulf PF

FSS CytoSulf PF is inspired by nature’s most resilient organisms—extremophiles capable of entering quiescent states in response to harsh conditions. Derived from Chlorobium tepidum and Sulfolobales through controlled fermentation, this extract contains bioavailable sulfide donors that mimic internal gasotransmitters, particularly sulfur dioxide (SO₂), known to regulate and slow cellular processes without causing cytotoxicity.

In skincare, these sulfide donors act by reducing cell cycle progression, specifically through modulation of key regulatory pathways such as cAMP/PKA and Erk/MAPK. This suspension of the cell cycle (cytostasis) mimics internal cellular signaling that preserves tissue by delaying aging processes—without initiating cellular damage or death.

Studies show that FSS CytoSulf PF can slow keratinocyte cell division at the G1 and G2-M phases, reduce wrinkle formation, and support the skin’s structural integrity by encouraging collagen synthesis and moisture retention. By extending the natural lifespan of skin cells, this extract introduces a novel, non-toxic pathway for anti-aging innovation.

Additionally, the plankton-derived components offer hydration, detoxifying, and protective benefits in both skin and scalp applications. When used in haircare, FSS CytoSulf PF helps reduce buildup, restore shine, and protect follicles.

Made Of:

FSS CytoSulf PF is derived from thermophilic microorganisms including Chlorobium tepidum, processed via fermentation to isolate sulfide donors. It is formulated without the odor or cytotoxicity typically associated with sulfur, and is water-soluble for versatile formulation.

Scientifically Proven

🧪 Cellular Viability Assay Analysis

FSS CytoSulf PF was tested on normal human dermal fibroblasts (NDHF) to assess its impact on cell health. At concentrations of 0.1% and 0.01%, neither the extract nor its preservative components inhibited cell viability. These results confirm that FSS CytoSulf PF enhances cellular viability at standard use levels.

🔥 IL-6 ELISA Analysis

In LPS-treated fibroblasts, FSS CytoSulf PF significantly reduced IL-6 production. This decrease in inflammatory markers suggests reduced inflammation in the skin environment, which may help minimize signs of aging such as fine lines and wrinkles. It confirms the extract’s soothing and anti-aging benefits.

💧 Moisturization Assay

FSS CytoSulf PF was shown to sustain increased moisture levels in the skin even after discontinuation of product application. Compared to untreated areas, the extract provided measurable improvements in skin hydration, indicating lasting moisturization effects.

🩹 Scratch Assay Analysis

In vitro scratch assay results demonstrated that FSS CytoSulf PF significantly increased cell migration, facilitating wound closure at a rate comparable to the positive control. These results mirror in vivo healing mechanisms, supporting its wound-healing and cell proliferation benefits.

🚫 Transepidermal Water Loss (TEWL) Assay

Over a four-week study, FSS CytoSulf PF reduced transepidermal water loss by 23.06% compared to the base cream, and by 32.05% compared to the untreated control. This shows the extract's ability to improve skin barrier function and support moisture retention over time.

🔍 High Resolution Skin Imaging Study

Skin density improved by 16.95% after one week and by 26.35% after four weeks of use compared to the untreated control. When compared to the base cream, improvements were 6.62% better after two weeks and 7.09% better after four weeks. These results indicate FSS CytoSulf PF supports firmer, denser skin structure over time.

🛡️ ORAC Assay Analysis Report

FSS CytoSulf PF demonstrated antioxidant activity comparable to 200 µM Trolox®. Its antioxidant efficacy was dose-dependent, confirming its ability to protect skin from oxidative stress and environmental damage.

⏳ Cytostasis Assay Analysis Report

Data showed that FSS CytoSulf PF can induce cytostasis, a process that slows cell cycle progression. This mechanism may help delay visible signs of aging and support preservation of youthful skin structure.

🌫️ In Vitro Airborne Pollutants Assay

FSS CytoSulf PF helped maintain cellular homeostasis when exposed to airborne pollutants. These results confirm its capacity to protect the skin at the cellular level against pollution-induced stress and damage.

Solubility

Water-Soluble

Use Levels

1.0-5.0%

Appearance

Clear to Slightly Hazy Liquid