FSS CytoSulf PF

INCI: Plankton Extract & Leuconostoc/Radish Root Ferment Filtrate

Use Levels: 1.0% - 5.0%

Solubility: Water Soluble

Appearance: Clear to Slightly Hazy Liquid
pH (25°C): 3.5 – 6.5

BACKGROUND

How we experience the passage of time is the essence of aging. Our cells age according to a clock described by biologists as the cell cycle. The passage from one phase to the next marks the progression of the lifespan

of a cell. The slower the cell moves through this cycle, the slower it ages and reaches its eventual senescence.

Studies have confirmed that certain organisms living in extreme conditions can become quiescent for extended periods of time, an ability that humans lack. It’s theorized that the quiescence seen by these certain species of extremophiles may be linked to cell cycle interruptions via sulfur-rich enzymes. The discovery of a new class of gasotransmitter has allowed scientists to achieve what was once solely the realm of science fiction – the suspension of the aging process.

The intersection of these ground breaking discoveries coupled with our expertise in bacterial fermentation has allowed us to capture specific sulfide donors from extreme prokaryotes such as Sulfolobales. These sulfide rich peptides in topical applications are able to slow the cellular aging process and deliver unique proaging benefits. For example, the Hayflick limit, or the number of times a cell can divide before its telomeres become too short for replication, is an excellent marker of aging. By prolonging a cell’s lifecycle you are effectively delaying aging which could result in perceivably less wrinkles, more taught, supple, or even softer skin.

SCIENCE

Current heart and lung tissue research focused on internal gasotransmitters (small gaseous molecules capable of signaling cells to induce both physical or chemical changes) suggests that sulfide donors can reduce damage in these tissues by decreasing the rate of cell cycle transition, specifically via sulfur dioxide. Internally, SO₂ plays a key role in the cross talk and regulation between pathways involved in cell stasis, such as cAMP/PKA and Erk/MAPK.^{2, 3}

That research found that SO₂ inhibited vascular smooth muscle cell division by preventing cell cycle progression from G1 to S phase and by DNA synthesis. Also important to note, findings supported that internal SO₂ did not influence vascular smooth muscle cell death in any way. Reducing it suspended the tissue in a type of stasis via suppression and control of the Erk/MAPK pathway mediated by cAMP/PKA signaling, without causing cell death.

As with the endogenous gasotransmitter SO₂, the Fucci cell cycle assay proves that this product can also halt the cell cycle of human skin cells, specifically in both the G2-M and G1 phase compared to the untreated controls. It is suspected that the oxidized sulfur from thermophilic cells act in the same fashion as internal SO₂, suspending human keratinocytes in a state of cytostasis.

By prolonging the cell cycle and reducing the rate of cell division, the potential for a new pathway and approach to anti-aging is here! One of the initial problems with utilizing sulfur as a method for inducing cell stasis is its assumed toxicity. By harnessing sulfide donors from Chlorobium tepidum, we have successfully eliminated the characteristic odor and cytotoxicity associated with sulfur based cosmetics. Using the formulaic components of elemental sulfur (sulfide donors), naturally derived from Chlorobium tepidum, FSS CytoSulf PF was engineered to increase cellular cyto-stasis while remaining procedurally simplistic to formulate with.

BENEFITS

FSS CytoSulf PF is the cutting edge of age defying beauty. The induction of cellular stasis through plankton derived sulfide donors is the perfect solution for permanently youthful skin. Without inducing cellular death, or overstimulating cell production, FSS CytoSulf PF is capable of suspending cells in a semi-permanent, drawn out stage of rest. For skin that defies aging through practical and understood science, FSS CytoSulf PF is the solution.

**FORMULATION GUIDELINES** 

Temperature Stability: Stable up to 70° Celsius

pH Stability: 4.0 – 7.0 pH

Suggested Use Levels: 1.0 – 5.0%

Solubility: 100% Water Soluble

Formulation Guidelines: Recommend adding to the aqueous phase, active phase, or cooling phase of the formula.

Storage: Protected from direct light and humidity at a temperature of 50°-77°F (10°-25°C) 

Shelf life: 12 months, properly stored, in sealed container. 

This product should be added to a formulation at the recommended usage rate.